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Research on Reducing Risk and Slowing Progression of Mild Cognitive Impairment and Alzheimer’s Disease.

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Training-related Brain Plasticity in Subjects at Risk of developing Alzheimer’s disease

Source: Belleville, S., Clement, F., Mellah, S. et al. BRAIN- A Journal of Neurology, doi:1093/brain/awr037, 2011.

This study examined memory training in 30 participants.  Of these, 15 had MCI and 15 were ‘normal’.  Participants were diagnosed with MCI after an extensive evaluation and must have had a memory complaint and scored 1.5 standard deviations or more below age adjusted norms on memory testing.  Patients were excluded if they had dementia or any impairment in activities of daily living.  Training consisted of two hour sessions administered weekly. The outcome measure was performance on a recall test administered before the intervention and one week after the intervention.   Results ”demonstrate that a systematic rehabilitation that provides a computerized cognitive training produces an improvement in cognitive [improved memory function] and affective status [decreased depression and anxiety] of patients with MCI and mild dementia, while a rehab program that doesn’t provide a punctual stimulation of cognitive functions doesn’t have significant effects” The finding that MCI patients experienced training effect on immediate and delayed recall after the intervention was found to be statistically significant.

Source: http://brain.oxfordjournals.org/content/early/2011/03/22/brain.awr037

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